Abstract: The Yan-Huai basin consists of four minor basins, namely, Yanqing, Huailai, Zhuo-lu and Fanshan basins. This region has been subjected to a progressive subsidence since Neogene. It may be regarded as a typical region for seismogeological study owing to great development of Quaternary sediments, sharp contrast in relief, concentration of historic earthquakes and distinct neotectonic movements.Six neotectonic categories may be recognized in the region under study basing upon the sedimentary history, geomorphological features and geophysical fields. In addition, a preliminary analysis of the seismic trend of the whole region is also made in the light of the different neotectonic activities, both young and old structural frameworks, and historic earthquakes.